Mystery of the Crooked Cell

NGSS-aligned with MS-LS1-A & LS3.A. This simple lab demonstrates detection of the mutation that causes Sickle Cell Anemia. In this simulation, your students will use electrophoresis to separate dyes that represent patient samples and controls. • Learn about sickle cell anemia and the mutations that cause it • Introduce the medical biotechnologies of restriction enzyme digestion and electrophoresis • Perform agarose gel electrophoresis to separate different sized dye molecules • Load, run, and analyze simulated patient samples and controls to diagnose this condition